Monotherapy in NSCLC 500 mg/m2 as IV infusion over 10 min on the 1sy days of each 21-day cycle. 500 mg/m2 IV infusion over 10 min on the 1st day of each 21-day cycle + cisplatin 75 mg/m2 infused approx 30 min after completion of Pemetrexed infusion on the 1st day of each 21-day cycle. Premedication regimen: Oral dexamethasone 4 mg bid prior to, on the day of, & the day after Pemetrexed administration to reduce incidence & severity of skin reactions. Vit supplementation: Oral folic acid or multivit containing folic acid 350-1,000 mcg daily to reduce toxicity.
