CAFONATE

Dosage

Advanced colorectal cancer Bimonthly regimen: Folinic acid 200 mg/m2 IV infusion over 2 hr, followed by 5-FU 400 mg/m2 IV bolus & 22-hr infusion of 5-FU 600 mg/m2 for 2 consecutive days every 2 wks on days 1 & 2. Wkly regimen: Folinic acid 20 mg/m2 IV bolus inj or 200-500 mg/m2 as IV infusion over 2 hr + IV bolus inj of 5-FU 500 mg/m2 in the middle or end of folinic acid infusion. Monthly regimen: Folinic acid 20 mg/m2 IV bolus inj or 200-500 mg/m2 as IV infusion over 2 hr immediately followed by IV bolus inj of 425 or 370 mg/m2 5-FU during 5 consecutive days.

Indication

Used as an antidote to folic acid antagonists.It is also used as an adjunct to fluorouracil in the treatment of colorectal cancer