ADROSAL 5

Dosage

Adult: As conventional formulation: As a single agent: 60-75 mg/m2 once every 3-4 weeks or 1.2-2.4 mg/kg once every 3 weeks. Alternatively, 20-25 mg/m2 may be given daily for 3 successive days every 3 or 4 weeks (although may increase the incidence of mucositis) or 20 mg/m2 once weekly. In combination with other antineoplastic agents: 30-60 mg/m2 every 3 weeks, or 40-75 mg/m2 every 21-28 days. Doses are administered via slow inj into a freely running IV infusion of 0.9% NaCl or 5% dextrose over 3-10 minutes. Alternatively, may also be given via continuous infusion through a central catheter. Total cumulative dose: 450-550 mg/m2.

Indication

Used in the treatment of Hodgkin’s disease, nonHodgkin’s lymphomas,acute leukemias,bone and soft tissue sarcomas, neuroblastoma, Wilm’s tumour, and malignant neoplasms of the bladder,breast,lung,ovary and thyroid